Enamide Synthesis by Copper‐Catalyzed Cross‐Coupling of Amides and Potassium Alkenyltrifluoroborate Salts

Abstract

A new partner: Potassium alkenyltrifluoroborate salts undergo coupling with amides to give enamides in the presence of a Cu(OAc)2 catalyst and under mild oxidative conditions (see scheme). The air- and water-stable alkenyltrifluoroborate salts offer a convenient alternative to alkenyl halides as cross-coupling partners. A range of amides undergo coupling including cyclic amides, imides, and carbamates as well as benzamides. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704711_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.