Effects of Vitamin E on the Aggregation and the Lipid Peroxidation of Platelets Exposed to Hydrogen Peroxide

Abstract

The hydrogen peroxide (H2O2)-induced platelet aggregation could be inhibited by vitamin E-nicotinate and less effectively by vitamin E-acetate. The adenosine diphosphate (ADP)-induced platelet aggregation could be slightly inhibited by vitamin E-nicotinate. The lipid peroxidation of platelet exposed to H2O2 could also be inhibited by vitamin E-nicotinate. The lipid peroxide formation associated with membrane disruption may be involved in the mechanism underlying the H2O2-induced platelet aggregation.