Concepedia

Publication | Open Access

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet β-Cells

DOIFull Paper Access

62

Citations

40

References

2011

Year

Katsuya Dezaki, Damdindorj Boldbaatar, Oleg Dyachok, Anders Tengholm, Erik Gylfe, Tomoyuki Kurashina, Masashi Yoshida, Masafumi Kakei, Toshihiko Yada
Diabetes

Abstract

Ghrelin directly interacts with islet β-cells to attenuate glucose-induced cAMP production and PKA activation, which lead to activation of Kv channels and suppression of glucose-induced [Ca(2+)](i) increase and insulin release.

References

YearCitations

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