EXPRESSION OF ANGIOTENSIN II TYPE I RECEPTOR ON ERYTHROID PROGENITORS OF PATIENTS WITH POST TRANSPLANT ERYTHROCYTOSIS1

Abstract

An increase in AT1R density was observed in erythroid precursors of transplant patients with PTE compared to those without PTE and normal volunteers, and the level of AT1R expression in PTE correlated significantly with the hematocrit. In contrast, EpoR expression was not different in PTE compared with non posttransplant erythrocytosis or normal controls. This study supports a role for the AT1 receptor signaling pathway in the pathogenesis of PTE.