Selective Inhibition of NF-κB Attenuates the Severity of Cerulein-Induced Acute Pancreatitis

Abstract

The marked induction of NF-kappaB binding activity suggests a role for this transcription factor in the early inflammatory changes associated with AP. Treatment with the NBD peptide attenuated the severity of injury associated with AP. Novel compounds that selectively target NF-kappaB may prove to be useful treatment of AP and AP-associated lung injury.