Smooth Muscle Cell–Specific Insulin-Like Growth Factor-1 Overexpression in <i>Apoe</i> ^−/− Mice Does Not Alter Atherosclerotic Plaque Burden but Increases Features of Plaque Stability

Abstract

These findings indicate that stimulation of VSMC IGF-1 signaling does not alter total atherosclerotic plaque burden and may improve atherosclerotic plaque stability.