Observations on 78 Thyrotoxic Patients Treated with Thiouracil

Abstract

INASMUCH as nearly 12 per cent of all cases treated with thiouracil have shown reactions of lesser or greater degree (38) it seems essential to collect data from large groups of patients before giving unqualified support to its widespread use. We reviewed the entire literature to June 1, 1944 Since that time at least 58 articles on thiouracil have appeared (3–38,40–42,44–52,54–64), of which 34 (3–7, 9–11, 14–16, 19, 22, 23, 25–27, 29, 30, 34–38, 40–44, 46, 50–52, 57, 59–62) summarize data from not less than 500 patients. Ten male and 68 female patients with thyrotoxicosis were studied while under treatment with thiouraci2 (Table 1) for periods ranging from two weeks to 16 months (Table 2). Forty-one patients were allowed to continue their usual routine of living. The remainder were hospitalized for long or short periods to permit continuous observation and more thorough investigation.