A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial - Concepedia

Concepedia

Publication | Open Access

A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

DOI Full Paper Access

139

Citations

12

References

2005

Year

Toshio Matsumoto, Takami Miki, Hiroshi Hagino, Toshitsugu Sugimoto, Sumiaki Okamoto, Takako Hirota, Yusuke Tanigawara, Yasufumi Hayashi, Masao Fukunaga, Masataka Shiraki,

The Journal of Clinical Endocrinology & Metabolism

Abstract

These results demonstrate that ED-71 treatment at around 0.75 microg/d can effectively and safely increase lumbar and hip BMD in osteoporotic patients with vitamin D supplementation.

References

	Year	Citations
Vitamin D<sub>3</sub>and Calcium to Prevent Hip Fractures in Elderly Women M C Chapuy, M Arlot, F. Duboeuf, New England Journal of Medicine	1992	2.9K
Diagnostic criteria for primary osteoporosis: year 2000 revision Hajime Orimo, Yasufumi Hayashi, Masao Fukunaga, Journal of Bone and Mineral Metabolism Bone DiseasePrimary OsteoporosisDiagnosisBone DensityMedicine	2001	463
Effects of 1?-hydroxyvitamin D3 on lumbar bone mineral density and vertebral fractures in patients with postmenopausal osteoporosis H. Orimo, Masataka Shiraki, Yujiro Hayashi, Calcified Tissue International Bone DiseaseBone HealthPostmenopausal OsteoporosisVertebral Fractures-Hydroxyvitamin D3	1994	224
Diagnostic criteria of primary osteoporosis Hajime Orimo, Youichi Sugioka, Masao Fukunaga, Journal of Bone and Mineral Metabolism Bone DiseasePrimary OsteoporosisDiagnosisOsteoarthritisBone Density	1998	209
A potent analog of 1α,25-dihydroxyvitamin D <sub>3</sub> selectively induces bone formation Nirupama K. Shevde, Lori A. Plum, Margaret Clagett‐Dame, Proceedings of the National Academy of Sciences	2002	175
ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis Yasushi Uchiyama, Y. Higuchi, Satoshi Takeda, Bone Estrogen-deficient Rat ModelBone ResorptionMedicineOsteoarthritisOsteoporosis	2002	120
2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts Hironori Yamamoto, Nirupama K. Shevde, Anjali Warrier, Journal of Biological Chemistry	2003	90
A novel synthetic vitamin D analogue, 2?-(3-hydroxypropoxy)1?, 25-dihydroxyvitamin D3 (ED-71), increases bone mass by stimulating the bone formation in normal and ovariectomized rats Hiroshi Tsurukami, Toshitaka Nakamura, K. Suzuki, Calcified Tissue International Orthopaedic SurgeryMedicineOsteoarthritisBone MassOvariectomized Rats	1994	87
A new active vitamin D analog, ED‐71, causes increase in bone mass with preferential effects on bone in osteoporotic patients Noboru Kubodera, Norihide Tsuji, Yasushi Uchiyama, Journal of Cellular Biochemistry	2003	49
Efficacy and Safety of Raloxifene 60 Milligrams/Day in Postmenopausal Asian Women Annie W.C. Kung, Hsiang‐Tai Chao, Ko-En Huang, The Journal of Clinical Endocrinology & Metabolism GynecologyHyperlipidemiaPharmacotherapyOsteoporosisBone Disease	2003	43

Page 1