Concepedia

Transient Upregulation of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Human Chorionic Gonadotropin Downregulates Autoimmune Diabetes

Aito Ueno, Suzanne Cho, Cheng Lu, Jianxiong Wang, Sheng Hou, Hiroko Nakano, Pere Santamaría, Yang Yang

Diabetes · 2007 · 69 citations · 26 references

DOIFull text

Open access

Abstract

We propose that hCG-induced upregulation of IDO in DCs plays a major role in pregnancy-associated resistance to autoimmunity.

References

26

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

David H. Munn, Min Zhou, John T. Attwood et al. · Science · 1998 · 2.6K citations

Regulatory T cells mediate maternal tolerance to the fetus

Varuna Aluvihare, Marinos Kallikourdis, Alexander G. Betz · Nature Immunology · 2004 · 1.6K citations

, , +7

GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

David H. Munn, Madhav Sharma, Babak Baban et al. · Immunity · 2005 · 1.2K citations · Full text

, , +12

CTLA-4–Ig regulates tryptophan catabolism in vivo

Ursula Grohmann, Ciriana Orabona, Francesca Fallarino et al. · Nature Immunology · 2002 · 1.1K citations

, , +6

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

David H. Munn, Madhav Sharma, De‐Yan Hou et al. · Journal of Clinical Investigation · 2004 · 839 citations · Full text

, , +18