Multifunctional Magneto‐Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer

Jaemoon Yang, Choong‐Hwan Lee, Hyun Ju Ko, Jin‐Suck Suh, Ho‐Geun Yoon, Kwangyeol Lee, Yong‐Min Huh, Seungjoo Haam

Angewandte Chemie International Edition · 2007 · 328 citations · 25 references

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Abstract

Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T2-weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA-MB-231 cells.

References

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