American Journal of Infectious Diseases · 2008 · 32 citations · 25 references
Veterinary MedicineGeriatric MedicineInfectious DiseasesClinical EpidemiologyEpidemiologyInfectious Disease EpidemiologyCause-specific MortalityComparative Morbidity PatternsInfectious Disease PathophysiologyInfectious Disease Risk FactorsMorbidity AnalysisMortality AnalysisAge-specific Morbidity PatternsChronic Renal InsufficiencyComparative Case Fatality RateDengue FeverDengue Hemorrhagic FeverFatality PatternsInfection Risk FactorsInfectious Disease Morbidity Patterns
In 2002, a dengue outbreak occurred in Taiwan with 5336 confirmed cases, 242 DHF and 21 death, the case fatality rate reached 8.7% (21/242). The demographic data of these age-specific dengue patients showed that dengue virus infection caused symptom primarily occurred in adults. A comparative analysis of clinical and laboratory data for DF, DHF/DSS and fatal DSS found that high fatality from dengue infection was associated with the following patient conditions: (1) age above 55 years, (2) underlying diseases with hypertension, chronic renal insufficiency, or diabetes, (3) abnormal thrombocytopenia, APTT and PT prolongation, low hematocrit (<30%) and leukocytosis, (4) abnormal elevation of AST, ALT and BUN. In a non-endemic area like Taiwan, dengue should be considered as an adult infectious disease and the dengue-infected elders will have higher morbidity or mortality.
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