Topological Characterization of Nucleic Acid G‐Quadruplexes by UV Absorption and Circular Dichroism

Abstract

Four-fold: Not just the identification, but also the rapid characterization and classification of nucleic acid G-quadruplexes into topology groups is feasible utilizing UV and circular dichroism (CD) spectroscopy (see picture). It is now possible to utilize inexpensive UV spectroscopy to achieve the same level of characterization previously only possible with CD spectroscopy.