CNS late‐effects after ALL therapy in childhood. Part III: Neuropsychological performance in long‐term survivors of childhood ALL: Impairments of concentration, attention, and memory*†‡

Abstract

Cranial irradiation in combination with MTX therapy was associated with deficits in attention, concentration, and the ability of sequencing and processing, measured by the Kaufman factor Freedom from Distractibility. Our results support the strategy of avoiding prophylactic CNS irradiation in low risk patients.