Angewandte Chemie International Edition · 2012 · 349 citations · 37 references
PharmacyBiomedical EngineeringOncologyDrug DeliveryNanomaterialsNanotechnologyCancer NanomedicineNanobiomaterialsNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsTheranostic NanoparticlesCancer NanotherapyCancer Photothermal TherapyGold Nanoparticle Drug DeliveryGold NanostructuresNanorodsStimuli-responsive Photothermal SystemsTargeted Photothermal TherapyTissue Penetration
Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.
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Nadine Wong Shi Kam, Michael O’Connell, Jeffrey Wisdom et al. · Proceedings of the National Academy of Sciences · 2005 · 2.3K citations · Full text