Lufaxin, a Novel Factor Xa Inhibitor From the Salivary Gland of the Sand Fly <i>Lutzomyia longipalpis</i> Blocks Protease-Activated Receptor 2 Activation and Inhibits Inflammation and Thrombosis In Vivo

Abstract

Lufaxin belongs to a novel family of slow-tight FXa inhibitors, which display antithrombotic and anti-inflammatory activities. It is a useful tool to understand FXa structural features and its role in prohemostatic and proinflammatory events.