Concepedia

Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables

David W. Ellison, Mehmet Koçak, James Dalton, Hisham Megahed, Meryl E. Lusher, Sarra Ryan, Wei Zhao, Sarah Leigh Nicholson, Roger Taylor, Simon Bailey,

Journal of Clinical Oncology · 2010 · 299 citations · 21 references

DOIFull text

Open access

Abstract

Integrating assays of molecular biomarkers undertaken on routinely collected diagnostic FFPE tissue into stratification schemes for medulloblastoma alongside clinical and pathologic outcome indicators can refine current definition of disease risk and guide adjuvant therapy.

References

21

An Introduction to Recursive Partitioning Using the RPART Routines

Terry M. Therneau, Elizabeth J. Atkinson · 2015 · 1K citations

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Phase III Study of Craniospinal Radiation Therapy Followed by Adjuvant Chemotherapy for Newly Diagnosed Average-Risk Medulloblastoma

Roger J. Packer, Amar Gajjar, Gilbert Vézina et al. · Journal of Clinical Oncology · 2006 · 973 citations

Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

Amar Gajjar, Murali Chintagumpala, David M. Ashley et al. · The Lancet Oncology · 2006 · 935 citations

, , +5

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

Marcel Kool, Jan Köster, Jens Bunt et al. · PLoS ONE · 2008 · 723 citations · Full text

Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations

Margaret C. Thompson, Christine Fuller, Twala L. Hogg et al. · Journal of Clinical Oncology · 2006 · 669 citations · Full text