Effects of Imipramine and Dextroamphetamine on Behavior of Neuropsychiatrically Impaired Children

Abstract

This study assessed the comparative effectiveness of imipramine, placebo, and dextroamphetamine as therapeutic agents for the control of hyperkinetic and aggressive behaviors in children. Behavioral change under the drug conditions was evaluated using a 39-item behavior rating scale. The results indicate that imipramine is an effective agent for the control of hyperactivity and aggression in behaviorally impaired children. Implications of the findings for clinical application in pediatric psychopharmacology are presented and discussed.