Deafness Following Standard Intravenous Dose of Ethacrynic Acid

TLDR

Abstract

Two nonuremic patients experienced neurosensory hearing loss after the intravenous administration of standard doses of ethacrynic acid. Both were receiving nontoxic doses of aminoglycoside antibiotics concurrently. Total deafness occurred within 15 minutes of the administration of ethacrynic acid and was not accompanied by vertigo, nausea, or vomiting. The impairment of hearing was clearly transient in one patient. In the other patient, results of histologic examination of the inner ear at the time of autopsy were normal.