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Publication | Open Access

DNA Methylation-Independent Reversion of Gemcitabine Resistance by Hydralazine in Cervical Cancer Cells

DOIFull Paper Access

51

Citations

52

References

2012

Year

Myrna Candelaria, Erick de la Cruz‐Hernandez, Lucía Taja‐Chayeb, Enrique Pérez‐Cárdenas, Catalina Trejo‐Becerril, Aurora González‐Fierro, Alma Chávez‐Blanco, Ernesto Soto‐Reyes, Guadalupe Domínguez-Gómez, Jaenai E. Trujillo,
PLoS ONE

Abstract

Our results demonstrate that acquired gemcitabine resistance is associated with DNA promoter methylation-independent hENT1 and dCK gene down-regulation and hyper-expression of G9A methyltransferase. Hydralazine reverts gemcitabine resistance in cervical cancer cells via inhibition of G9A histone methyltransferase.

References

YearCitations

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