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CONVERSION OF SOME SYNTHETIC PROGESTINS TO OESTROGEN
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1964
Year
Hormonal ContraceptiveFertilityReproductive HealthGynecologyOestrogen OutputReproductive BiologySynthetic ProgestinsOvarian CancerReproductive EndocrinologyPublic HealthSteroid MetabolismAromataseUrinary Oestrogen ExcretionEndocrinologyPharmacologyOvarian HormonePlacental FunctionUrologyUterine ReceptivityMedicineEndocrine ResearchReproductive Hormone
ABSTRACT The effects of oral administration of synthetic progestins on the urinary oestrogen excretion were examined. 17α-ethynyl-19-nortestosterone (ENT) or 17α-ethynyl-estr-4-en-17β-ol (EEL) caused a significant rise of oestrogen output in urine. It appeared that the increased output of oestrogen was due to the conversion of ENT or EEL to ethynyl-oestradiol (EE2). Such a conversion of progestin was also observed with 17α-methyl-19-nortestosterone. To obtain the direct evidence for the conversion of ENT to EE2, human placental homogenates were incubated in vitro first with 19-nortestosterone. The approximate yield of oestrone was 20 percent of that observed with testosterone. However, a conversion of ENT to EE2 was not detected.