The Journal of Experimental Medicine · 1916 · 76 citations · 0 references
Life SciencesImmunologyInfectious DiseasesImmunology Of Infectious DiseasesInnate ImmunityMicrobial PathogenesisHost Defense Against InfectionImmune SystemPhagocyte BiologyProtective ImmunityTissue DamageTissue Response To InfectionCell-mediated Antimicrobial DefenseInfection-induced Tissue DamagePhagocyte Antimicrobial ActivityPhagocyte EvasionPhagocytic ActivityPhagocytosis Of Bacteria
1. Living phagocytes are able to protect ingested organisms from the action of destructive substances in the surrounding fluid, and even from a strong homologous antiserum. 2. There is evidence that the protection by phagocytes is largely if not entirely conditioned on their being alive. 3. These facts should be taken into consideration in the study of diseases caused by infectious agents capable of living within tissue cells.