The Fine Structure of Fibrin

Abstract

SUMMARY Using negatively staining techniques fibrin clots have been examined by electron microscopy, and finer detail of the clot structure has been observed than previously reported. From these observations a model of fibrinogen is proposed having different dimensions from those which are generally accepted and it is suggested that the fibrin clot is formed by end‐to‐end polymerization of the monomer with a one third molecular length overlap between laterally adjacent fibrils.