Antimuscarinics Suppress Adenosine Triphosphate and Prostaglandin E2 Release From Urothelium With Potential Improvement in Detrusor Overactivity in Rats With Cerebral Infarction

Abstract

Results support the hypothesis or suggest that imidafenacin improves cerebral infarction induced detrusor overactivity by suppressing peripheral C-fibers. This effect is thought to be associated with suppression of the release of adenosine triphosphate and prostaglandin E(2) from the urothelium.