Concepedia

Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease

Taketoshi Asanuma, Masafumi Ono, Kei Kubota, Akira Hirose, Yoshihiro Hayashi, Toshiji Saibara, Osamu Inanami, Yasuhiro Ogawa, Hideaki Enzan, Saburo Onishi,

Gut · 2009 · 68 citations · 28 references

DOI

Abstract

KC uptake function is significantly impaired in patients with NAFLD and experimental animals with NASH, worsens with the degree of steatosis and is not due to a reduction of KC numbers.

References

28

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

David E. Kleiner, Elizabeth M. Brunt, Mark L. Van Natta et al. · Hepatology · 2005 · 10.5K citations

, , +24

Long‐term follow‐up of patients with NAFLD and elevated liver enzymes†‡

Mattias Ekstedt, Lennart Franzén, Ulrik Mathiesen et al. · Hepatology · 2006 · 2.3K citations

Leptin regulates proinflammatory immune responses

S. Loffreda, Shiqi Yang, Huizhi Lin et al. · The FASEB Journal · 1998 · 1.2K citations

, , +17

Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

S. J. Creely, Philip G. McTernan, Christine M. Kusminski et al. · American Journal of Physiology-Endocrinology and Metabolism · 2006 · 1K citations

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

Shi Qi Yang, Hui Lin, M. Daniel Lane et al. · Proceedings of the National Academy of Sciences · 1997 · 809 citations · Full text

, , +22