Stimulation of Guanosine-5′-O-(3-[35S]Thio)Triphosphate Binding by Endogenous Opioids Acting at a Cloned Mu Receptor

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

A potent and selective endogenous agonist for the µ-opiate receptor

James E. Zadina, Laszlo Hackler, Lin-Jun Ge et al. · Nature · 1997 · 1.3K citations

Medicine, Medicinal Chemistry, Pharmacology +12

A MODIFICATION OF RECEPTOR THEORY

R. P. STEPHENSON · British Journal of Pharmacology and Chemotherapy · 1956 · 1.1K citations · Full text

Medicine, Pharmacology, Chemical Kinetics +15

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

John R. Traynor, Stefan R. Nahorski · Molecular Pharmacology · 1995 · 462 citations

Life Sciences, Biochemistry, Pharmacology +17

Cloning and pharmacological characterization of a rat μ opioid receptor

Robert C. Thompson, Alfred Mansour, Huda Akil et al. · Neuron · 1993 · 457 citations · Full text

Medicine, Neuroscience, Pharmacology +12