Antibiotic use and the risk of carbapenem-resistant extended-spectrum- -lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: results of a double case-control study

Abstract

This study highlights the major role of treatment and duration of treatment with β-lactam/β-lactamase inhibitor combinations and combinations of carbapenems with fluoroquinolones. Clinicians should counterweight the potential benefits of administering these antibiotics against the increased risk of ESBL-CRKP infection.