FEMS Microbiology Letters · 1995 · 35 citations · 13 references
Life SciencesBiologyMicrobiologyMedical MicrobiologyMicrobial PathogenesisMycologyFungal InfectionsFungal PathogenesisFungal PhysiologyOral Fungal InfectionsYeast BiologyYeast GeneticsAnimal Model EvaluationCandida Albicans InfectionCandida-host InteractionsFungal Oral InfectionsHybrid StrainsOral Mucosal Fungal PathogenesisVirulence Factor RegulationYeast Morphogenesis
The virulence of Candida albicans strain SC5413 and two isogenic derivatives have been investigated in a rat model of oropharyngeal candidiasis. The results demonstrate that both mutant strains are avirulent in this animal model while the parental strain readily initiates infection. Avirulence is not related to altered growth characteristics or the inability of the strains to undergo yeast-to-hyphal morphogenesis. The potential importance of nutritional sufficiency as a virulence factor as well as the possibility of utilizing such strains in the development of an in vitro expression technology system for Candida albicans is discussed.
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Isogenic strain construction and gene mapping in Candida albicans.
William A. Fonzi, M Y Irwin · Genetics · 1993 · 1.7K citations · Full text