Immunosuppressor FK506 Increases Endoglin and Activin Receptor-Like Kinase 1 Expression and Modulates Transforming Growth Factor-β1 Signaling in Endothelial Cells

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

Kimberly A. McAllister, K.M. Grogg, David W. Johnson et al. · Nature Genetics · 1994 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

Toru Kino, Hiroshi Hatanaka, MICHISANE HASHIMOTO et al. · The Journal of Antibiotics · 1987 · 1.2K citations · Full text

Medicine, Biochemistry, Pharmacology +10

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

Toru Kino, Hiroshi Hatanaka, Susumu Miyata et al. · The Journal of Antibiotics · 1987 · 1.2K citations · Full text

Medicine, Immunology, Pharmacology +9

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

David W. Johnson, Jonathan Berg, Melanie A. Baldwin et al. · Nature Genetics · 1996 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +8

Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction

Franck Lebrin, Marie‐José Goumans, Leon Jonker et al. · The EMBO Journal · 2004 · 648 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12