Antimicrobial Agents and Chemotherapy · 2007 · 29 citations · 15 references
Public HealthImmunologyPharmacotherapyClinical ImmunologyImmunopharmacologyTuberculosis ControlAntiretroviral TherapyImmunomodulatory DrugsTuberculosis PharmacotherapyTuberculosis PreventionAdrenal Hormone MetabolismAdrenal Hormone PharmacologyAdrenal Hormone RegulationHiv-associated Opportunistic InfectionsHuman Immunodeficiency Virus-associated TuberculosisOpportunistic Infections In ImmunodeficiencyTuberculosis In Immunocompromised Hosts
Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. The drug was well tolerated and safe and reduced both the incidence of tuberculosis coinfection by 42.2% (P < 0.05) and the cumulative incidence of opportunistic infections (P < 0.05). These results warrant further clinical investigation of HE2000.
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The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Frederick P. Siegal, Norimitsu Kadowaki, Michael Shodell et al. · Science · 1999 · 2.2K citations
Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients
Vassili Soumelis, Iain Scott, Ferdous Gheyas et al. · Blood · 2001 · 389 citations · Full text