The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: The melanocortin agonist paradigm

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis

Ronald N. Zuckermann, Janice M. Kerr, Stephen B. H. Kent et al. · Journal of the American Chemical Society · 1992 · 1.2K citations

Combinatorial Chemistry, Bioorganic Chemistry, Efficient Method +18

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Nina Balthasar, Louise T. Dalgaard, Charlotte E. Lee et al. · Cell · 2005 · 1.1K citations · Full text

Obesity, Nutrition, Melanocortin Pathways +13

Peptoids: a modular approach to drug discovery.

Reyna J. Simon, Robert S. Kania, Ronald N. Zuckermann et al. · Proceedings of the National Academy of Sciences · 1992 · 935 citations · Full text

Diverse Libraries, Drug Target, Bioorganic Chemistry +14

Comparison of the proteolytic susceptibilities of homologous L‐amino acid, D‐amino acid, and N‐substituted glycine peptide and peptoid oligomers

Susan M. Miller, Reyna J. Simon, Simon Ng et al. · Drug Development Research · 1995 · 420 citations

Protein Chemistry, Glycine Peptide, N‐substituted Glycine Peptide +14

Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability:  Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides

Taha Rezai, Jonathan Bock, Mai V. Zhou et al. · Journal of the American Chemical Society · 2006 · 409 citations

Membrane Structure, Proteinlipid Interaction, Biochemistry +12