Hypoxia differentially affects IL-1 -stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1 -dependent manner

Abstract

Hypoxia in arthritic joints may differentially affect the IL-1β-stimulated expression of MMP-1 and MMP-13 in rheumatoid synovial fibroblasts. This effect is dependent on HIF-1α expression. This hypoxia-mediated differential effect should be taken into consideration when testing the efficiency of therapies that target HIF-1α.