Concepedia

Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells

Heming Li, Ling Xu, Ce Li, Lei Zhao, Yanju Ma, Hua‐chuan Zheng, Zhi Li, Ye Zhang, Ruoyu Wang, Yunpeng Liu,

Molecular Cancer · 2014 · 95 citations · 37 references

DOIFull text

Open access

Abstract

Together, these findings demonstrate that the ubiquitin ligase Cbl-b represses IGF-I-induced EMT, likely through targeting IGF-IR for degradation and further inhibiting the Akt/ERK-miR-200c-ZEB2 axis in gastric cancer cells.

References

37

Cancer Statistics, 2009

Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians · 2009 · 9.7K citations · Full text

, , +18

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

Philip A. Gregory, Andrew G. Bert, Emily Paterson et al. · Nature Cell Biology · 2008 · 3.8K citations

, , +9

Hepatogastroenterology

Yadong Wang, Caiyan Zhao, Wei Wang et al. · Hepatogastroenterology · 2012 · 1.6K citations

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2

Manav Korpal, Esther S. Lee, Guohong Hu et al. · Journal of Biological Chemistry · 2008 · 1.6K citations · Full text

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

Cameron P. Bracken, Philip A. Gregory, Natasha Kolesnikoff et al. · Cancer Research · 2008 · 1.1K citations · Full text