A Newer Application of Physically Modified Gellan Gum in Tablet Formulation using Factorial Design

Abstract

This study examines the physically modified gellan gum in tablet formulation i.e., as a superdisintegrant. Physical cross-liking of gellan gum was carried out using microwave energy and it was subjected to Differential Scanning Calorimetry and Fourier Transform � Infra Red. Swelling ratio of pure and modified gellan gum was performed. Tablets of were formulated containing modified gellan gum using 32 randomized full factorial designs. It was observed that physical modification on gellan gum was done by microwave energy and was confirmed by Differential Scanning Calorimetry and Fourier Transform � Infra Red. Modified gellan gum has superior swelling ratio than pure. It was observed that optimized batch shows excellent disintegration time (155 s), and % drug release in 2 and 5 min were 39 and 78%, respectively. It was concluded that there was a no chemical interactions while only physical modification and modified gellan gum can work as a superdisintegrant.