The Journal of Experimental Medicine · 2005 · 165 citations · 40 references
Life SciencesImmunologyMolecular BiologyCell SignalingMolecular ImmunologySignal TransductionB Cell ActivationB Cell BiologyB Cell Receptor SignalingImmune Cell SignalingLymphocyte ActivationProtein Kinase CascadesActivationAdaptor Protein Complex 1Adaptor Protein RecruitmentAntigen Receptor SignalingB Cell Receptor ActivationMap KinasesNuclear Factor Kappa B ActivationNuclear Factor Kappa B Modulation
The B cell antigen receptor (BCR)-mediated activation of IkappaB kinase (IKK) and nuclear factor-kappaB require protein kinase C (PKC)beta; however, the mechanism by which PKCbeta regulates IKK is unclear. Here, we demonstrate that another protein kinase, TGFbeta-activated kinase (TAK)1, is essential for IKK activation in response to BCR stimulation. TAK1 interacts with the phosphorylated CARMA1 (also known as caspase recruitment domain [CARD]11, Bimp3) and this interaction is mediated by PKCbeta. IKK is also recruited to the CARMA1-Bcl10-mucosal-associated lymphoid tissue 1 adaptor complex in a PKCbeta-dependent manner. Hence, our data suggest that phosphorylation of CARMA1, mediated by PKCbeta, brings two key protein kinases, TAK1 and IKK, into close proximity, thereby allowing TAK1 to phosphorylate IKK.
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Atsuhiro Kanayama, Rashu B. Seth, Lijun Sun et al. · Molecular Cell · 2004 · 869 citations · Full text