Concepedia

Randomized Phase III Study of High-Dose Fluorouracil Given As a Weekly 24-Hour Infusion With or Without Leucovorin Versus Bolus Fluorouracil Plus Leucovorin in Advanced Colorectal Cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952

C-H Köhne, J. Wils, M. Lorenz, Patrick Schöffski, R. Voigtmann, Carsten Bokemeyer, Manfred P. Lutz, Ulrich R. Kleeberg, Karsten Ridwelski, R. Souchon,

Journal of Clinical Oncology · 2003 · 158 citations · 14 references

DOI

Abstract

Neither FU24h + LV nor FU24h prolong survival, relative to bolus FU + LV. Leucovorin increases PFS if added to FU24h, but increases toxicity.

References

14

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, , +13

Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer.

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