Synthesis of 5-Thio-L-Fucose and its Inhibitory Effect on Fucosidase

Abstract

ABSTRACT 5-Thio-L-fucose was synthesized for the first time from D-glucose in 16 steps and -found to have a remarkable inhibitory effect on fucosidases from bovine epididymis (Ki 4.2x10−5 M) and kidney (Ki 8.4 x 10−5 M).