Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

Jeremy Brown, Bradly G. Wouters · PubMed · 1999 · 702 citations

Medicine, Cancer Biology, Oncology +17

SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

Michael Maceyka, Heidi Sankala, Nitai C. Hait et al. · Journal of Biological Chemistry · 2005 · 635 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

Kevin J. French, Yan Zhuang, Lynn W. Maines et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 315 citations · Full text

Medicine, Oncology, Pharmacology +17

Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells

Yusuf Baran, Arelis Salas, Can E. Senkal et al. · Journal of Biological Chemistry · 2007 · 211 citations · Full text

Medicine, Cancer Biology, Pharmacology +16

FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1

Dmitri Pchejetski, Torsten Böhler, Leyre Brizuela et al. · Cancer Research · 2010 · 146 citations · Full text

Medicine, Oncology, Pharmacology +17