Chemical Synthesis of an Erythropoietin Glycoform Containing a Complex‐type Disialyloligosaccharide

Abstract

New and improved: New reaction conditions for tert-Boc-based solid-phase peptide synthesis make acid-labile sialyloligosaccharyl peptide α-thioesters accessible. To demonstrate this, a sialyloligosaccharyl-erythropoietin glycoform (see picture) with 166 amino acid residues was synthesized.