Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Chloé James, Valérie Ugo, Jean‐Pierre Le Couedic et al. · Nature · 2005 · 3.5K citations

Life Sciences, Genetics, Molecular Biology +7

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

Geneviève P. Delcuve, Dilshad H. Khan, James Davie · Clinical Epigenetics · 2012 · 503 citations · Full text

Medicine, Molecular Biology, Pharmacology +13

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

Sriram Balasubramanian, Jason Ramos, Weigang Luo et al. · Leukemia · 2008 · 446 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

Ina Oehme, Hedwig E. Deubzer, Dennis Wegener et al. · Clinical Cancer Research · 2008 · 401 citations · Full text

Medicine, Cancer Biology, Oncology +14

Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

Daniela Ungureanu, Pipsa Saharinen, Ilkka Junttila et al. · Molecular and Cellular Biology · 2002 · 258 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17