Concepedia

Discovery of 3-OH-3-methylpipecolic hydroxamates: Potent orally active inhibitors of aggrecanase and MMP-13

Mark C. Noe, Vijayalakshmi Natarajan, Sheri L. Snow, Lilli A. Wolf‐Gouveia, Peter G. Mitchell, Lori Lopresti‐Morrow, Lisa M. Reeves, Sue A. Yocum, Ivan G. Otterness, Marcia A. Bliven,

Bioorganic & Medicinal Chemistry Letters · 2005 · 37 citations · 4 references

DOIFull text

Open access

Concepts

References

4

A Convenient in vitro Screening Method for Predicting in vivo Drug Metabolic Clearance Using Isolated Hepatocytes Suspended in Serum

Yoshihiro Shibata, Yasuyuki Ishii · Drug Metabolism and Disposition · 2000 · 80 citations

, , +17

Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors

Michael A. Letavic, Matt Z. Axt, John T. Barberia et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 75 citations · Full text

, , +8

Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Venkatesan Aranapakam, Jamie M. Davis, G Grosu et al. · Journal of Medicinal Chemistry · 2003 · 70 citations · Full text

, , +11

Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13

Mark C. Noe, Vijayalakshmi Natarajan, Sheri L. Snow et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 44 citations · Full text

, , +7