Total Synthesis of Chondramide C and Its Binding Mode to F‐Actin

Abstract

Actin glue: An E-selective ring-closing metathesis as the key step allowed the solid-phase-based total synthesis of the F-actin stabilizer chondramide C as well as the establishment of its hitherto unknown stereochemistry. A strong influence of the polyketide configuration was revealed in cellular assays. Docking studies on the F-actin filament structure led to a detailed model of the binding site. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.