The occurrence of neutralizing and complement fixing antibodies in rubella

Abstract

Neutralization and complement-fixation tests to detect rubella antibody are described. Results of such tests show that between 80 and 95% of adults in England and Wales have neutralizing antibody. The presence of complement-fixing antibody indicates recent infection with rubella virus. Results are presented showing the development of neutralizing and complement-fixing antibody after rubella. Antibody tests on children with congenital rubella and their mothers are detailed. It is noted that higher neutralizing antibody titres are found in this group than in the general population.