Self‐Healing Microencapsulation of Biomacromolecules without Organic Solvents

Samuel E. Reinhold, Kashappa Goud H. Desai, Li Zhang, Karl Olsen, Steven P. Schwendeman

Angewandte Chemie International Edition · 2012 · 91 citations · 21 references

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Abstract

Capture and seal off all exits! Biomacromolecules are routinely microcapsulated in poly(lactic-co-glycolic acid) (PLGA) in multiple complex steps that are deleterious to the biomacromolecule. In contrast, PLGA encapsulation based on self-healing (see picture) shows high efficiency without protein damage and enables the stabilization and slow release of proteins. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

References

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