Concepedia

A small molecule inhibitor of p53-inducible protein phosphatase PPM1D

Hiroaki Yagi, Yoshiro Chuman, Yuuki Kozakai, Toshiaki Imagawa, Yu Takahashi, Fumihiko Yoshimura, Keiji Tanino, Kazuyasu Sakaguchi

Bioorganic & Medicinal Chemistry Letters · 2011 · 39 citations · 25 references

DOIFull text

Open access

Concepts

References

25

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

Sheau-Yann Shieh, Masako Ikeda, Yoichi Taya et al. · Cell · 1997 · 2.1K citations · Full text

, , +13

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

Michele Fiscella, Hongliang Zhang, Saijun Fan et al. · Proceedings of the National Academy of Sciences · 1997 · 542 citations

, , +17

p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation

Mutsuhiro Takekawa, Masaaki Adachi, Atsuko Nakahata et al. · The EMBO Journal · 2000 · 422 citations · Full text

, , +17

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK–mediated activation of the p16Ink4a-p19Arf pathway

Dmitry V. Bulavin, Crissy Phillips, Bonnie Nannenga et al. · Nature Genetics · 2004 · 408 citations · Full text

, , +16

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Xiongbin Lu, Bonnie Nannenga, Lawrence A. Donehower · Genes & Development · 2005 · 384 citations · Full text

, , +15