Cardiovascular Responses to the Isoprostanes iPF_2α-III and iPE₂-III Are Mediated via the Thromboxane A₂Receptor In Vivo

Abstract

Both iPF(2alpha)-III and iPE(2)-III exert their effects on platelet function and vascular tone in vivo by acting as incidental ligands at membrane TPs rather than via a distinct iP receptor. Activation of TPs by iPs may be of importance in syndromes in which cyclooxygenase activation and oxidant stress coincide, such as in atherosclerosis and reperfusion after tissue ischemia.