Publication | Closed Access
DELAYED HYPERSENSITIVITY IN VITRO. II. EFFECT OF SENSITIVE CELLS ON NORMAL CELLS IN THE PRESENCE OF ANTIGEN.
215
Citations
0
References
1964
Year
Clinical ImmunologyLaboratory ImmunologyCellular ImmunologyImmunologyImmune RegulationPathologyHumoral ResponseAntigen ProcessingImmunotherapyHypersensitivitySensitive CellsAllergyAutoimmune DiseaseAutoimmunitySelf-toleranceHumoral ImmunityTolerance InductionCell BiologyMixed PopulationImmunomodulationNormal CellsMedicine
Summary Peritoneal exudate cells from guinea pigs exhibiting delayed hypersensitivity to tuberculin and from normal animals were mixed in varying proportions, and their migration in the presence of specific antigens was studied. The results indicate that only a few cells in a mixed population need be specifically sensitive to influence the behavior of the whole population. Killing the sensitive cells abolishes their effect on normal cells. Some questions raised by these results are discussed.