Diffusion and defect data, solid state data. Part B, Solid state phenomena/Solid state phenomena · 2007 · 15 citations · 4 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanoparticle Drug DeliveryPharmaceutical FormulationEmulsion FormulationLipid-based Drug Delivery SystemsLipid-based NanoparticlesNanoparticle CharacterizationNanoparticle FormulationsSurfactantsEncapsulationEncapsulation EfficiencyLipid Nanoparticle SynthesisLipid NanoparticlesNanocarrier Encapsulation EfficiencySolid Lipid EncapsulationSolid Lipid Nanoparticle EncapsulationTransdermal Absorption
Solid lipid nanoparticles(SLN) appear a promising approach as a drug system for topical application. The solid lipid matrices allow protection of incorporated active ingredients against chemical and physical degradation. This paper deals with controllable preparation of solid lipid nanoparticles based on the phase behaviors of hot microemulsions. The pseudoternary phase diagram for the system of glyceryl monostearate(GMS)/ mixed surfactants (polyoxyethylene(40) stearate(S-40) and poloxamer 188 (F-68))/ water was obtained at 60 °C using self-made apparatus with temperature control. The mass ratios of glyceryl monostearate(GMS), mixed surfactants and water were determined according to the region of w/o hot microemulsion. It was shown that the size of TP-SLN increased slightly with the increasing of concentration of TP, polydispersity index was approximately 0.5, encapsulation efficiency decreased distinctly. The percutaneous absorption experiment of tea polyphenols loaded SLN through the rabbit skin were conducted using self-made Franz diffusion cell in vitro. The transdermal penetration was sustained.
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Säntosh K. Katiyar, Farrukh Afaq, Kashif Azizuddin et al. · Toxicology and Applied Pharmacology · 2001 · 271 citations