Journal de Physique IV (Proceedings) · 2001 · 23 citations · 0 references
Natural SciencesChemistryMaterials ScienceMaterials CharacterizationPhysical ChemistrySolid-state ChemistryCrystallographyPhase AnalysisSolid-state CharacterizationThermogravimetric AnalysisX-ray CrystallographyX-ray DiffractionPowder DiffractionPowder Diffraction AnalysisPowder X-ray DiffractionX-ray Diffraction AnalysisX-ray Diffraction Phase Analysis
Docetaxel, a stoichiometric hydrate containing three water molecules per molecule of drug substance, is thermodynamically stable under ambient conditions of pressure, temperature and relative humidity. Dehydration of this form was subjected to X-ray powder diffraction (XRPD) and thermogravimetric experiments. To obtain a better understanding of the observed structural changes between trihydrate and dehydrated forms, the crystalline structure of docetaxel was refined using high resolution XRPD data coupled with an ab initio direct space method.