The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Shan Zhu, Irina G. Stavrovskaya, Martin Drozda et al. · Nature · 2002 · 1.1K citations

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

Heng Du, Lan Guo, Shiqiang Yan et al. · Proceedings of the National Academy of Sciences · 2010 · 705 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

Marcus J. Calkins, Maria Mańczak, Peizhong Mao et al. · Human Molecular Genetics · 2011 · 646 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Caspase signalling controls microglia activation and neurotoxicity

Miguel Ángel Burguillos, Tomas Deierborg, Edel Kavanagh et al. · Nature · 2011 · 590 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

Marcello D’Amelio, Virve Cavallucci, Silvia Middei et al. · Nature Neuroscience · 2010 · 568 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16