all‐<scp>D</scp>‐Polypeptides: Novel Targets for Semisynthesis

Abstract

The chemoenzymatic synthesis of all-D-polypeptides such as the all-D version of the WW domain of hPin1 (1) was achieved by applying the substrate mimetics strategy and clostripain as the biocatalyst. Ironically all-D-peptides are better synthesis targets for proteases than their all-L analogues, although nature designed these enzymes for the cleavage of all-L-peptides.